Epithelial Mesenchymal Transition: a double‐edged sword
نویسندگان
چکیده
منابع مشابه
Epithelial Mesenchymal Transition: a double-edged sword
Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pathways have different regulations from those of normal physiology. In cancer invasion, such a mechanism leads to generation of circulating tumor cells. Epithelial cancer cells become motile...
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Owing to this fact that most of the mortalities in cancers are as a result of metastasis, study on the involved pathways in metastasis including Epithelial to mesenchymal transition (EMT) would be so critical and important. Up to date, several extensive studies have been carried out to determine the correlation between EMT and cancer and their results have shown that the EMT plays pivotal role ...
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Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...
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Pathology and NYU Cancer Institute, NYU Langone Medical Center, New York, New York; OSI Pharmaceuticals, Farmingdale, New York; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York; and Department of Surgery, University of Melbourne, St. Vincent’s Hospi...
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ژورنال
عنوان ژورنال: Clinical and Translational Medicine
سال: 2015
ISSN: 2001-1326,2001-1326
DOI: 10.1186/s40169-015-0055-4